標(biāo)志性成果 |
1. 科研項目 [1] 國家自然科學(xué)基金委員會, 青年科學(xué)基金項目, 82204022, 高鹽膳食上調(diào)TMEM16A介導(dǎo)肌漿網(wǎng)RyR2異常磷酸化在冠 狀動脈重構(gòu)中的作用機制研究, 2023-01-01 至 2025-12-31, 30萬元, 在研, 主持 [2] 國家衛(wèi)生健康委員會塵肺病重點實驗室 2023 年度開放課題面上項目, NHC202307,杜鵑素下調(diào)縫隙連接蛋白 Cx43 改善二氧化硅致肺動脈重塑的機制研究,2024-01-01 至 2025-12-31, 10萬元, 在研, 主持 [3] 山西省科技廳, 山西省自然科學(xué)研究面上項目, 202103021224227, ANO1介導(dǎo)肌漿網(wǎng)RyR2磷酸化在高鹽 膳食致冠狀動脈重構(gòu)中的調(diào)控機制, 2022-01 至 2024-12, 10萬元, 已結(jié)題,主持 [4] 山西省留學(xué)人員管理辦公室, 山西省回國留學(xué)人員科研資助項目, 2020-075, 基于鈣激活氯通道研究 杜鵑素防治鹽敏感高血壓冠脈重構(gòu)的機制, 2020-08 至 2023-07, 5萬元, 已結(jié)題,主持 2. 學(xué)術(shù)論文 [1] XIAOMIN HOU XIAOJIANG QIN; QINGSHAN LI*; Structure-activity associations in novel farrerol derivatives with vasorelaxant properties, Mol Med Rep, 2018, 18(5): 4709-4715. [2] Xiaomin Hou; Yu Liu; LonggangNiu; Lijuan Cui; Mingsheng Zhang*; Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery, Planta Med, 2014, 80(6): 465-472. [3] Xinrong Xu#, Xiaomin Hou# (共同第一作者), Ye Xing, Tianfeng Feng, Lina Chai, Yunting Guo, Liangjing Chen, Yiwei Shi, Xiaojiang Qin*. Dibazol-induced relaxation of ophthalmic artery in C57BL/6J mice is correlated with the potency to inhibit voltage-gated Ca2+ channels. Exp Eye Res. 2023, 231: 109468. [4] Xiaojiang Qin, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Anqi Gao, Yuxuan Hao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li*. Down-regulation of connexin 43 contributes to structure and function of pulmonary artery in nicotine-administered mice. Toxicol Lett. 2023,377(15): 1-13. [5] Xiaojiang Qin,Anqi Gao,Xiaomin Hou,Xinrong Xu,Liangjin Chen,Lin Sun,Yuxuan Hao,Yiwei Shi. Connexins may play a critical role in cigarette smoke-induced pulmonary hypertension. Arch Toxicol. 2022,12(04): 308-312. [6] Xiaojiang Qin#; Xiaomin Hou#(共同第一作者); Kun Zhang; Qingshan Li*; α1D-adrenoceptor involves the relaxation effect of farrerol in rat aortic vascular smooth muscle cells, Eur J Pharmacol, 2019, 853:169-183. [7] Xiaojiang Qin#; Xiaomin Hou#(共同第一作者); Kun Zhang; Qingshan Li*; Farrerol Modulates Aorta Gene Expression Profile in Spontaneously Hypertensive Rats, Planta Med, 2018, 84(5): 296-303. [8] Xiaojiang Qin; Xinrong Xu; Xiaomin Hou; Ruifeng Liang; Liangjing Chen; Yuxuan Hao; Anqi Gao; Xufeng Du; Liangyuan Zhao; Yiwei Shi; Qingshan Li*; The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review, PharmBiol, 2021, 60(1): 9-16. [9] YANG R, LIU Y, HOU X(侯曉敏), Fan Y, Li J, Chen M, Wang Y, Zhang X, Zhang M. MAPKs-mediated modulation of the myocyte voltage-gated K(+) channels is involved in ethanol-induced rat coronary arterial contraction. Eur J Pharmacol, 2018, 834: 274-80. [10] 侯曉敏,施熠煒,孫琳,趙旭,鄭志發(fā),常銘洋,張明升,秦小江(通訊作者). 高鹽飲食上調(diào)跨膜蛋白16A致C57BL/6J小鼠腦動脈重構(gòu)的機制. 中國藥理學(xué)通報. 2023,39(06): 1042-1047. [11] 侯曉敏, 張明升, 秦小江. 杜鵑素通過增強Kv1.5和Kv2.1表達(dá)抑制尼古丁所致的肺動脈平滑肌細(xì)胞增殖. 中國病理生理雜志, 2019, 35(07): 1276-82. [12] 侯曉敏, 秦小江, 張明升. 槲皮素對自發(fā)性高血壓大鼠大腦中動脈張力與縫隙連接蛋白43表達(dá)的影響. 中國臨床藥理學(xué)雜志, 2018, 34(24): 2821-4. 3. 科技獎勵 [1] 侯曉敏(1/3); 《Structure-activity associations in novel farrerol derivatives with vasorelaxant properties》, 太原市科學(xué)技術(shù)協(xié)會, 自然科學(xué), 其他, 2019(侯曉敏侯曉敏; 秦小江; 李青山) (科研獎勵科研獎勵,二等獎) 4. 發(fā)明專利 [1] 李青山; 秦小江; 侯曉敏; 韓玲革; 班樹榮; 石磊。杜鵑素與其衍生物及其可藥用鹽在制備由血管收縮引起的心腦血管疾病藥物中的應(yīng)用。(專利號:ZL201110303137.0) [2] 侯曉敏;秦小江;郭戍辰;施熠煒;聶繼盛;陳亮京;郝雨萱;葛帥帥;馬雁軍。一種高效快速培養(yǎng)小鼠原代肺動脈內(nèi)皮細(xì)胞培養(yǎng)基的制備及應(yīng)用。(申請?zhí)枺?02310131063.X) |